The Role of Childhood Trauma in Affective Stress Recovery in Early Psychosis: An Experience Sampling Study

Author:

Ader Leonie1ORCID,Schick Anita1ORCID,Vaessen Thomas234, ,Alizadeh Behrooz Z56,van Amelsvoort Therese7,Cahn Wiepke89,de Haan Lieuwe1011,Schirmbeck Frederike1011,Simons Claudia J P712,van Os Jim1314,Veling Wim5,Morgan Craig1516,Kempton Matthew J17,Valmaggia Lucia181920,McGuire Philip1721,Myin-Germeys Inez2,Lafit Ginette222,Reininghaus Ulrich11623

Affiliation:

1. Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University , Mannheim , Germany

2. Department of Neurosciences, Center for Contextual Psychiatry, KU Leuven , Leuven , Belgium

3. Department of Psychology, Health & Technology, Faculty of Behavioural, Management and Social Sciences (BMS), University of Twente , Enschede , The Netherlands

4. Department of Neurosciences, Mind Body Research, KU Leuven , Leuven , Belgium

5. Department of Psychiatry, Rijksuniversiteit Groningen, University Medical Center Groningen , Groningen , Netherlands

6. University Medical Center Groningen, Department of Epidemiology , Groningen , The Netherlands

7. Maastricht University Medical Center, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht , The Netherlands

8. University Medical Center Utrecht, Department of Psychiatry, Brain Centre Rudolf Magnus, Utrecht University , Utrecht , The Netherlands

9. Altrecht, General Mental Health Care , Utrecht , The Netherlands

10. Amsterdam UMC, University of Amsterdam, Department of Psychiatry , Amsterdam , The Netherlands

11. Arkin, Institute for Mental Health , Amsterdam , The Netherlands

12. GGzE Institute for Mental Health Care , Eindhoven , The Netherlands

13. University Medical Center Utrecht, Department of Translational Neuroscience, Brain Center Rudolf Magnus , Utrecht , The Netherlands

14. King’s College London, King’s Health Partners, Department of Psychosis Studies, Institute of Psychiatry , London , United Kingdom

15. Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London , London , UK

16. ESRC Centre for Society and Mental Health, King’s College London , London , UK

17. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London , London , UK

18. Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London , London , UK

19. South London and Maudsley NHS Foundation Trust , London , UK

20. Department of Psychiatry, KU Leuven , Leuven , Belgium

21. Department of Psychiatry, University of Oxford, Warneford Hospital , Oxford , UK

22. Research Group of Quantitative Psychology and Individual Differences, Faculty of Psychology, KU Leuven , Leuven , Belgium

23. Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King’s College London , London , UK

Abstract

Abstract Background and Hypotheses Affective recovery, operationalized as the time needed for affect to return to baseline levels after daily stressors, may be a putative momentary representation of resilience. This study aimed to investigate affective recovery in positive and negative affect across subclinical and clinical stages of psychosis and whether this is associated with exposure to childhood trauma (sexual, physical, and emotional abuse). Study Design We used survival analysis to predict the time-to-recovery from a daily event-related stressor in a pooled sample of 3 previously conducted experience sampling studies including 113 individuals with first-episode psychosis, 162 at-risk individuals, and 94 controls. Study Results Negative affective recovery (ie, return to baseline following an increase in negative affect) was longer in individuals with first-episode psychosis compared with controls (hazard ratio [HR] = 1.71, 95% confidence interval [CI; 1.03, 2.61], P = .04) and in at-risk individuals exposed to high vs low levels of emotional abuse (HR = 1.31, 95% CI [1.06, 1.62], P = .01). Positive affective recovery (ie, return to baseline following a decrease in positive affect) did not differ between groups and was not associated with childhood trauma. Conclusions Our results give first indications that negative affective recovery may be a putative momentary representation of resilience across stages of psychosis and may be amplified in at-risk individuals with prior experiences of emotional abuse. Understanding how affective recovery contributes to the development of psychosis may help identify new targets for prevention and intervention to buffer risk or foster resilience in daily life.

Funder

German Federal Ministry of Education and Research

German Research Foundation

ERC Consolidator

FWO Odysseus

NWO VENI

Publisher

Oxford University Press (OUP)

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