Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome-Reference-Cited by-同舟云学术

Speech Illusions in People at Clinical High Risk for Psychosis Linked to Clinical Outcome

Published:2022-12-14 Issue:2 Volume:49 Page:339-349
ISSN:0586-7614
Container-title:Schizophrenia Bulletin
language:en
Short-container-title:

Author:

Hird Emily J¹^ORCID,Ohmuro Noriyuki¹²³,Allen Paul¹⁴,Moseley Peter⁵^ORCID,Kempton Matthew J¹,Modinos Gemma¹^ORCID,Sachs Gabriele⁶^ORCID,van der Gaag Mark⁷⁸⁹,de Haan Lieuwe¹⁰¹¹,Gadelha Ary¹²,Bressan Rodrigo¹²,Barrantes-Vidal Neus¹³^ORCID,Ruhrmann Stephan¹⁴,Catalan Ana¹¹⁵^ORCID,McGuire Philip¹⁶,Valmaggia Lucia R¹⁷,Kempton Matthew J¹⁶,Calem Maria¹⁶,Tognin Stefania¹⁶,Modinos Gemma¹⁶,de Haan Lieuwe¹⁰¹¹,van der Gaag Mark¹⁸⁹,Velthorst Eva¹⁰¹⁹,Kraan Tamar C¹⁰,van Dam Daniella S¹⁰,Burger Nadine⁹,Nelson Barnaby²⁰,McGorry Patrick²⁰,Paul Amminger Günter²⁰,Pantelis Christos²⁰,Politis Athena²⁰,Goodall Joanne²⁰,Riecher-Rössler Anita²¹,Borgwardt Stefan²¹,Rapp Charlotte²¹,Ittig Sarah²¹,Studerus Erich²¹,Smieskova Renata²¹,Bressan Rodrigo¹²,Gadelha Ary¹²,Brietzke Elisa²²,Asevedo Graccielle¹²,Asevedo Elson¹²,Zugman Andre¹²,Barrantes-Vidal Neus¹³,Domínguez-Martínez Tecelli²³,Torrecilla Pilar²⁴,Kwapil Thomas R²⁵,Monsonet Manel²⁴,Hinojosa Lídia²⁴,Kazes Mathilde²⁶,Daban Claire²⁶,Bourgin Julie²⁶,Gay Olivier²⁶,Mam-Lam-Fook Célia²⁶,Krebs Marie-Odile²⁶,Nordholm Dorte²⁷,Randers Lasse²⁷,Krakauer Kristine²⁷,Glenthøj Louise²⁷,Glenthøj Birte²⁸,Nordentoft Merete²⁷,Ruhrmann Stephan¹⁴,Gebhard Dominika¹⁴,Arnhold Julia²⁹,Klosterkötter Joachim¹⁴,Sachs Gabriele⁶,Lasser Iris⁶,Winklbaur Bernadette⁶,Delespaul Philippe A³⁰³¹,Rutten Bart P³⁰,van Os1 Jim³⁰,McGuire Philip¹,

Affiliation:

1. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London , London , UK

2. Department of Psychiatry, Tohoku University Hospital , Sendai, Miyagi , Japan

3. Department of Psychiatry, Osaki Citizen Hospital , Osaki , Japan

4. School of Psychology, Whitelands College, University of Roehampton , Holybourne Ave, London, SW15 4JD , UK

5. Psychology Department, Northumbria University , College Lane, Newcastle-Upon-Tyne, NE1 8ST , UK

6. Department of Psychiatry and Psychotherapy, Medical University of Vienna , Vienna , Austria

7. Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology, VU University , van der Boechorststraat 1, 1081 BT Amsterdam , The Netherlands

8. EMGO Institute for Health and Care Research, VU University , van der Boechorststraat 1, 1081 BT Amsterdam , The Netherlands

9. Department of Psychosis Research, Parnassia Psychiatric Institute , Zoutkeetsingel 40, 2512 HN The Hague , The Netherlands

10. Department Early Psychosis, AMC, Academic Psychiatric Centre , Meibergdreef 5, 1105 AZ Amsterdam , The Netherlands

11. Arkin , Amsterdam , The Netherlands

12. LiNC - Lab Interdisciplinar Neurociências Clínicas, Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo – UNIFESP , São Paulo , Brazil

13. Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona), Fundació Sanitària Sant Pere Claver (Spain), Spanish Mental Health Research Network (CIBERSAM) , Barcelona , Spain

14. Department of Psychiatry and Psychotherapy, University of Cologne , Cologne , Germany

15. Psychiatry Department, Biocruces Bizkaia Health Research Institute, OSI Bilbao-Basurto, Facultad de Medicina y Odontología, University of the Basque Country UPV/EHU, Centro de Investigación en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III , Plaza de Cruces 12, 48903 Barakaldo, Bizkaia , Spain

16. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London , De Crespigny Park, Denmark 458 Hill, London, SE5 8AF , UK

17. Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London , De Crespigny Park, Denmark Hill, 456, London, SE5 8AF , UK

18. Faculty of Behavioural and Movement Sciences, Department of Clinical Psychology and EMGO Institute for Health and Care Research , VU University, van der Boechorststraat 1, 1081 BT Amsterdam , The Netherlands

19. Department of Psychiatry, Icahn School of Medicine at Mount Sinai , 1425 Madison Ave, New York, NY 10029 , USA

20. Centre for Youth Mental Health, University of Melbourne , 35 Poplar Road (Locked Bag 10), Parkville, Victoria 485 3052 , Australia

21. University Psychiatric Hospital , Wilhelm Klein-Strasse 27, CH-4002 Basel , Switzerland

22. Depto Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo – UNIFESP , São Paulo , Brazil

23. CONACYT-Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (México) , Mexico City , Mexico

24. Departament de Psicologia Clínica i de la Salut (Universitat Autònoma de Barcelona) , Barcelona , Spain

25. Department of Psychology, University of Illinois at Urbana-Champaign , IL , USA

26. University Paris Descartes, Hôpital Sainte-Anne, C’JAAD, Service HospitaloUniversitaire, Inserm U894, Institut de Psychiatrie (CNRS 3557) Paris , France

27. Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen , Copenhagen , Denmark

28. Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen , Glostrup , Denmark

29. Psyberlin , Berlin , Germany

30. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre , PO Box 616, 6200 MD 464 Maastricht , The Netherlands

31. Mondriaan Mental Health Trust , PO Box 4436 CX Heerlen , The Netherlands

Abstract

Abstract Background and hypothesis Around 20% of people at clinical high risk (CHR) for psychosis later develop a psychotic disorder, but it is difficult to predict who this will be. We assessed the incidence of hearing speech (termed speech illusions [SIs]) in noise in CHR participants and examined whether this was associated with adverse clinical outcomes. Study design At baseline, 344 CHR participants and 67 healthy controls were presented with a computerized white noise task and asked whether they heard speech, and whether speech was neutral, affective, or whether they were uncertain about its valence. After 2 years, we assessed whether participants transitioned to psychosis, or remitted from the CHR state, and their functioning. Study results CHR participants had a lower sensitivity to the task. Logistic regression revealed that a bias towards hearing targets in stimuli was associated with remission status (OR = 0.21, P = 042). Conversely, hearing SIs with uncertain valence at baseline was associated with reduced likelihood of remission (OR = 7.72. P = .007). When we assessed only participants who did not take antipsychotic medication at baseline, the association between hearing SIs with uncertain valence at baseline and remission likelihood remained (OR = 7.61, P = .043) and this variable was additionally associated with a greater likelihood of transition to psychosis (OR = 5.34, P = .029). Conclusions In CHR individuals, a tendency to hear speech in noise, and uncertainty about the affective valence of this speech, is associated with adverse outcomes. This task could be used in a battery of cognitive markers to stratify CHR participants according to subsequent outcomes.

Funder

European Network of National Schizophrenia Networks Studying Gene Environment Interactions

European Community’s Seventh Framework Programme

Medical Research Council Fellowship

Innovación e Universidades to N Barrantes-Vidal

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

Link

https://academic.oup.com/schizophreniabulletin/article-pdf/49/2/339/49534040/sbac163.pdf

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