Data From the World Health Organization’s Pharmacovigilance Database Supports the Prominent Role of Pneumonia in Mortality Associated With Clozapine Adverse Drug Reactions

Author:

De Leon Jose1,Sanz Emilio J2,De las Cuevas Carlos3

Affiliation:

1. Mental Health Research Center at Eastern State Hospital, Lexington, KY

2. Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands, Spain

3. Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, University of La Laguna, Canary Islands, Spain

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

Reference4 articles.

1. Clozapine and long-term mortality risk in patients with schizophrenia: a systematic review and meta-analysis of studies lasting 1.1–12.5 years;Vermeulen;Schizophr Bull,2019

2. A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults;Cicala;Expert Rev Clin Pharmacol,2019

3. Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report;de Leon;Prog Neuropsychopharmacol Biol Psychiatry,2003

4. Pneumonia may be more frequent and have more fatal outcomes in clozapine than in other second-generation antipsychotics;de Leon;World Psychiatry,2019

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