Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia

Author:

Cao Hengyi123,Wei Xia1,Zhang Wenjing1ORCID,Xiao Yuan1,Zeng Jiaxin1,Sweeney John A14,Gong Qiyong1ORCID,Lui Su1

Affiliation:

1. Department of Radiology and National Clinical Research Center for Geriatrics, Huaxi MR Research Center, West China Hospital of Sichuan University , Chengdu , China

2. Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research , Manhasset, NY , USA

3. Division of Psychiatry Research, Zucker Hillside Hospital , Glen Oaks, NY , USA

4. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , Cincinnati, OH , USA

Abstract

Abstract Background Cerebellar functional dysconnectivity has long been implicated in schizophrenia. However, the detailed dysconnectivity pattern and its underlying biological mechanisms have not been well-charted. This study aimed to conduct an in-depth characterization of cerebellar dysconnectivity maps in early schizophrenia. Study design Resting-state fMRI data were processed from 196 drug-naïve patients with first-episode schizophrenia and 167 demographically matched healthy controls. The cerebellum was parcellated into nine functional systems based on a state-of-the-art atlas, and seed-based connectivity for each cerebellar system was examined. The observed connectivity alterations were further associated with schizophrenia risk gene expressions using data from the Allen Human Brain Atlas. Study results Overall, we observed significantly increased cerebellar connectivity with the sensorimotor cortex, default-mode regions, ventral part of visual cortex, insula, and striatum. In contrast, decreased connectivity was shown chiefly within the cerebellum, and between the cerebellum and the lateral prefrontal cortex, temporal lobe, and dorsal visual areas. Such dysconnectivity pattern was statistically similar across seeds, with no significant group by seed interactions identified. Moreover, connectivity strengths of hypoconnected but not hyperconnected regions were significantly correlated with schizophrenia risk gene expressions, suggesting potential genetic underpinnings for the observed hypoconnectivity. Conclusions These findings suggest a common bidirectional dysconnectivity pattern across different cerebellar subsystems, and imply that such bidirectional alterations may relate to different biological mechanisms.

Funder

National Natural Science Foundation of China

National Key R&D Program of China

CAMS Innovation Fund for Medical Sciences

Sichuan Science and Technology Program

1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University

Humboldt Foundation Friedrich Wilhelm Bessel Research Award and Chang Jiang Scholars

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

Reference75 articles.

1. The role of the cerebellum in Schizophrenia;Andreasen;Biol Psychiat.,2008

2. Cerebellar dysfunction and Schizophrenia: from “Cognitive Dysmetria” to a potential therapeutic target;Cao;Am J Psychiatry.,2019

3. Cerebellar structural and functional abnormalities in first-episode and drug-naive patients with schizophrenia: a meta-analysis;Ding;Psychiatry Res Neuroimag.,2019

4. “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?;Andreasen;Schizophr Bull.,1998

5. Cerebellar abnormalities in first-episode, drug-naive schizophrenia at rest;Guo;Psychiatry Res Neuroimag.,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3