A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models

Author:

Berthet Pierre12,Haatveit Beathe C12,Kjelkenes Rikka12,Worker Amanda3,Kia Seyed Mostafa456,Wolfers Thomas127ORCID,Rutherford Saige489,Alnaes Dag12ORCID,Dinga Richard6,Pedersen Mads L12,Dahl Andreas12,Fernandez-Cabello Sara12,Dazzan Paola3,Agartz Ingrid21011,Nesvåg Ragnar12,Ueland Torill12,Andreassen Ole A2,Simonsen Carmen210,Westlye Lars T12ORCID,Melle Ingrid2,Marquand Andre48

Affiliation:

1. Department of Psychology, University of Oslo , Oslo , Norway

2. Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital , Oslo , Norway

3. Department of Psychosis Studies, Institute of Psychiatry, King’s College , London , UK

4. Donders Institute for Brain, Cognition, and Behaviour, Radboud University , Nijmegen , the Netherlands

5. Department of Psychiatry, Utrecht University Medical Center , Utrecht , the Netherlands

6. Department Cognitive Science and Artificial Intelligence, Tilburg University , the Netherlands

7. Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen , Tübingen , Germany

8. Department of Cognitive Neuroscience, Radboud University Medical Center , Nijmegen , the Netherlands

9. Department of Psychiatry, University of Michigan , Ann Arbor, MI , USA

10. Department of Psychiatric Research, Diakonhjemmet Hospital , Oslo , Norway

11. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet , Stockholm , Sweden

12. Department of Mental Disorders, Norwegian Institute of Public Health , Oslo , Norway

Abstract

Abstract Background Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year longitudinal study, we aimed to characterize the temporal evolution of cortical correlates of psychosis and their associations with symptoms. Design Structural magnetic resonance imaging (MRI) from people with first-episode psychosis and controls (n = 79 and 218) were obtained at enrollment, after 12 months (n = 67 and 197), and 10 years (n = 23 and 77), within the Thematically Organized Psychosis (TOP) study. Normative models for cortical thickness estimated on public MRI datasets (n = 42 983) were applied to TOP data to obtain deviation scores for each region and timepoint. Positive and Negative Syndrome Scale (PANSS) scores were acquired at each timepoint along with registry data. Linear mixed effects models assessed effects of diagnosis, time, and their interactions on cortical deviations plus associations with symptoms. Results LMEs revealed conditional main effects of diagnosis and time × diagnosis interactions in a distributed cortical network, where negative deviations in patients attenuate over time. In patients, symptoms also attenuate over time. LMEs revealed effects of anterior cingulate on PANSS total, and insular and orbitofrontal regions on PANSS negative scores. Conclusions This long-term longitudinal study revealed a distributed pattern of cortical differences which attenuated over time together with a reduction in symptoms. These findings are not in line with a simple neurodegenerative account of schizophrenia, and deviations from normative models offer a promising avenue to develop biomarkers to track clinical trajectories over time.

Funder

Wellcome Trust

Research Council of Norway

KG Jebsen Stiftelsen

European Research Council

South-Eastern Norway Regional Health Authority

Publisher

Oxford University Press (OUP)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3