Nuclear protein of the testis midline carcinoma of the thorax-Reference-Cited by-同舟云学术

Nuclear protein of the testis midline carcinoma of the thorax

Published:2022-03-23 Issue:6 Volume:52 Page:531-538
ISSN:1465-3621
Container-title:Japanese Journal of Clinical Oncology
language:en
Short-container-title:

Author:

Saiki Ayae¹²^ORCID,Sakamoto Keita¹²,Bee Yuan³²,Izumo Takehiro¹²

Affiliation:

1. Department of Respiratory Medicine , , Tokyo, Japan

2. Japanese Red Cross Medical Center , , Tokyo, Japan

3. Department of Pathology , , Tokyo, Japan

Abstract

Abstract Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare tumor that typically presents in the head, neck, and chest region. NMC is characterized by rearrangement of the NUTM1 gene. It mainly affects children and young adults and is rapidly progressive and lethal. Reportedly, the prognoses of NMCs of the head and neck improve following aggressive initial surgical resection +/− postoperative chemoradiotherapy (CRT) or radiotherapy (RT). However, as NMC of the thorax was identified later, treatments to improve its prognosis are yet to be identified. Our review reveals that NMC is an extremely rare cancer, and most patients remain undiagnosed. Furthermore, this review outlines the clinical characteristics of NMC of the thorax and the prospects for its treatment.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

Link

https://academic.oup.com/jjco/article-pdf/52/6/531/43900302/hyac033.pdf

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