Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases

Author:

Furukawa Kenei1ORCID,Onda Shinji1,Taniai Tomohiko1,Hamura Ryoga1,Kumamoto Tomotaka1,Shirai Yoshihiro1,Yasuda Jungo1,Haruki Koichiro1ORCID,Shiozaki Hironori1,Gocho Takeshi1,Ikegami Toru1

Affiliation:

1. Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan

Abstract

Abstract Introduction The aim of this study is to investigate the relationship between preoperative serum transferrin level and long-term outcomes in patients with colorectal liver metastases after hepatic resection. Methods We retrospectively investigated 72 patients who underwent hepatic resection for colorectal liver metastases and explored the relationship between serum transferrin level and long-term outcomes. Results In multivariate analysis, H3 (odds ratio 3.43, 95% confidence interval 1.11–10.89 and P = 0.03) was an independent and significant predictor of the disease-free survival, and a transferrin level ≥ 190 mg/dl (odds ratio 0.20, 95% confidence interval 0.05–0.79 and P = 0.02) and the time to recurrence after hepatectomy <1 year (odds ratio 11.30, 95% confidence interval 2.63–48.59 and P < 0.01) were independent and significant predictors of the overall survival. Conclusions The serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

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