Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group

Author:

Hiraga Hiroaki1ORCID,Ozaki Toshifumi2

Affiliation:

1. Department of Musculoskeletal Oncology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan

2. Department of Orthopedic Surgery, Okayama University Hospital, Okayama, Japan

Abstract

Abstract The usefulness of adjuvant chemotherapy for high-grade osteosarcoma was established by two randomized, controlled trials conducted in the 1980s, which used six drugs, doxorubicin, cisplatin, high-dose methotrexate, bleomycin, cyclophosphamide and actinomycin D. Since then, development has been promoted in the direction of introducing preoperative chemotherapy, changing post-operative adjuvant chemotherapy according to histological effects, adding ifosfamide as a key drug and strengthening adjuvant chemotherapy. No clinical trials, however, have shown the effectiveness of study treatment, and the improvement of treatment results during that time has been slight, although the JCOG0905 study is now going to verify the effectiveness of introducing ifosfamide for patients who experienced limited preoperative therapeutic effects. We are desperately looking for a breakthrough.

Funder

National Cancer Center Research and Development Fund

Japan Agency for Medical Research and Development

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

Reference19 articles.

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2. Doxorubicin in disseminated osteosarcoma;Cores;JAMA,1972

3. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity;Link;N Engl J Med,1986

4. Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study;Link;Clin Orthop,1991

5. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial;Eilber;J Clin Oncol,1987

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