Adjuvant and neoadjuvant chemotherapy for biliary tract cancer: a review of randomized controlled trials

Author:

Nakachi Kohei1,Gotohda Naoto2,Hatano Etsuro34,Nara Satoshi5ORCID,Takahashi Shinichiro6,Kawamoto Yasuyuki7,Ueno Makoto89

Affiliation:

1. Department of Medical Oncology, Tochigi Cancer Center , Utsunomiya , Japan

2. Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East , Kashiwa , Japan

3. Department of Surgery , Graduate School of Medicine, , Kyoto , Japan

4. Kyoto University , Graduate School of Medicine, , Kyoto , Japan

5. Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital , Tokyo , Japan

6. Department of Gastroenterological Surgery, Tokai University School of Medicine , Isehara , Japan

7. Division of Cancer Center, Hokkaido University Hospital , Sapporo , Japan

8. Department of Gastroenterology , Hepatobiliary and Pancreatic Medical Oncology Division, , Yokohama , Japan

9. Kanagawa Cancer Center , Hepatobiliary and Pancreatic Medical Oncology Division, , Yokohama , Japan

Abstract

Abstract The first randomized controlled trial of adjuvant chemotherapy for biliary tract cancer was reported in 2002. Since then, studies have continued, with efficacy reported for capecitabine in 2018 and S-1 in 2023. Oral fluoropyrimidines have become established as the standard of care. This article reviews the evidence from the randomized controlled trials reported to date and those that are ongoing or from which results have not yet been reported.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

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