Plasmablastic lymphoma of the rectum: case report of a rare location and literature review

Author:

AlMohamedi Razan Saleh12,AlRajban Waleed12ORCID,AlRikabi Ammar12,Arafah Maha12

Affiliation:

1. Department of Pathology, King Khaled University Hospital, Riyadh, Saudi Arabia

2. Department of Pathology, King Saud University, Riyadh, Saudi Arabia

Abstract

Abstract Plasmablastic lymphoma (PBL) is an aggressive and rare variant of diffuse large B-cell lymphoma, which is thought to occur in immunocompromised individuals, specifically HIV-positive patients. We report the case of a 27-year-old Saudi male with PBL. The patient had a low CD4 count at presentation, however, he was HIV negative at the time of diagnosis; also Human herpesvirus-8 was negative on immunohistochemical stain, but Epstein–Barr virus showed expression in scattered cells through the utilization of EBV-EBER.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference6 articles.

1. Plasmablastic lymphoma associated with adjacent mature plasma cell population exhibiting opposite light chain restriction;Furlan;Case Rep Pathol,2020

2. Clinical characteristics and prognostic factors of plasmablastic lymphoma patients: analysis of 135 patients from the LYSA group;Tchernonog;Annals of oncology: official journal of the European Society for Medical Oncology US National Library of Medicine

3. Human immunodeficiency virus-negative plasmablastic lymphoma: a case report and literature review;Lin;Medicine,2017

4. Plasmablastic lymphoma phenotype is determined by genetic alterations in MYC and PRDM1;Montes-Moreno;Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc US National Library of Medicine

5. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection;Delecluse;Blood,1997

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