A rare case of small cell carcinoma of the ovary, hypercalcemic type

Author:

Boujida Ismail1234ORCID,Mahdi Y1234,Khmou M1234,Ech-charif S1234,Horache K3452,El-Aoufir O3452,Gamra L6,El-Khannoussi B1234

Affiliation:

1. Department of Pathology of the National Institute of Oncology , , Rabat 10100 , Morocco

2. Ibn Sina University Hospital Center , , Rabat 10100 , Morocco

3. Faculty of Medicine and Pharmacy , , Rabat 10100 , Morocco

4. Mohammed 5 University , , Rabat 10100 , Morocco

5. Department of Radiology , , Rabat 10100 , Morocco

6. Pathology Center Hassan , Rabat 10100 , Morocco

Abstract

Abstract Small cell carcinoma of ovary, hypercalcemic type (SCCOHT) is an unusual malignant tumor that most commonly affects young women. Unfortunately, it has a very poor prognosis. We describe here an unusual case of a Moroccan young woman with a left ovarian mass and a symptomatic hypercalcemia. Morphologically, there are some malignant tumors that resemble SCCOHT; thus, it is very challenging to diagnose, and immunohistochemistry has a great contribution in it. Hopefully, molecular tools and new therapies will improve the management of these cases in the near future.

Publisher

Oxford University Press (OUP)

Reference9 articles.

1. Small cell carcinoma of the ovary (hypercalcemic type): malignant rhabdoid tumor;Kascak;Case Rep Oncol,2016

2. An in-depth look at small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): clinical implications from recent molecular findings;Lu;J Cancer,2019

3. Carcinome à petites cellules de l’ovaire;Bahri;Cancer/Radiothérapie,2014

4. Small cell carcinoma of the ovary, hypercalcaemic type - genetics, new treatment targets and current management guidelines;Tischkowitz;Clin Cancer Res,2020

5. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4;Ramos;Nat Genet,2014

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