Sevelamer crystals—an unusual cause of large bowel obstruction

Author:

Cockrell Hannah C1,Cottrell-Cumber Sarah1,Brown Kathryn2,Murphy Jason G3

Affiliation:

1. Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA

2. Department of Pathology, Mississippi Baptist Hospital, Jackson, MS, USA

3. Surgical Clinic Associates, Mississippi Baptist Hospital, Jackson, MS, USA

Abstract

Abstract Sevelamer is a common phosphate binder used to manage hyperphosphatemia in end-stage renal disease. The medication has a well-documented gastrointestinal side-effect profile including nausea, vomiting and abdominal pain. There are few case reports of Sevelamer crystal deposition causing gastrointestinal mucosal injury, pseudotumor or obstruction. Here, we discuss a patient on Sevelamer who required operative management of a sigmoid obstruction. Surgical pathology showed pericolonic abscess with Sevelamer crystals.

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference5 articles.

1. Gastrointestinal complications induced by sevelamer crystals;Yuste;Clin Kidney J,2017

2. Sevelamer crystals in the gastrointestinal tract: a new entity associated with mucosal injury;Swanson;Am J Surg Pathol,2013

3. Hematochezia associated with Sevalamer-induced mucosal injury;Chintamaneni;ACG Case Rep J,2014

4. Colonic mucosal ulceration and gastrointestinal bleeding associated with sevelamer crystal deposition in a patient with end stage renal disease;Nambiar;Case Rep Nephrol,2018

5. Sevelamer-induced colitis presenting as a pseudotumor;Okwara;Clin Gastroenterol Hepatol,2015

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