Thera-SAbDab: the Therapeutic Structural Antibody Database

Author:

Raybould Matthew I J1ORCID,Marks Claire1ORCID,Lewis Alan P2,Shi Jiye3ORCID,Bujotzek Alexander4,Taddese Bruck5ORCID,Deane Charlotte M1ORCID

Affiliation:

1. Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles’, Oxford OX1 3LB, UK

2. Data and Computational Sciences, GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage SG1 2NY, UK

3. Chemistry Department, UCB Pharma, 216 Bath Road, Slough SL1 3WE, UK

4. Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, DE-82377 Penzberg, Germany

5. Discovery Sciences Department, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK

Abstract

Abstract The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 5 August 2019) are downloadable as a single file with accompanying metadata.

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

GlaxoSmithKline plc.

AstraZeneca plc

F. Hoffmann-La Roche

UCB Celltech

Publisher

Oxford University Press (OUP)

Subject

Genetics

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