Phenytoin-Induced Depletion of Folate in Rats Originates in Liver and Involves a Mechanism That Does Not Discriminate Folate Form-Reference-Cited by-同舟云学术

Phenytoin-Induced Depletion of Folate in Rats Originates in Liver and Involves a Mechanism That Does Not Discriminate Folate Form

Published:1997-11-01 Issue:11 Volume:127 Page:2231-2238
ISSN:0022-3166
Container-title:The Journal of Nutrition
language:en
Short-container-title:

Author:

Carl G. Franklin¹,Hudson Farlyn Z.²,McGuire Byron S.²

Affiliation:

1. Department of Neurology, Medical College of Georgia, Augusta, GA 30912

2. Medical Research Service, VA Medical Center, Augusta, GA 30904

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Link

http://academic.oup.com/jn/article-pdf/127/11/2231/24025028/2231.pdf

Reference25 articles.

1. Decreased hepatic 5, 10-methylenetetrahydrofolate reductase activity in mice after chronic phenytoin treatment;Billings;Molec. Pharmacol.,1984

2. The effect of chronic phenytoin treatment on tissue folate concentrations and on the activities of the methyl synthetic enzymes in the rat;Carl;J. Nutr.,1983

3. Rat liver subcellular folate distribution shows association of formyltetrahydropteroylpentaglutamates with mitochondria and methyltetrahydropteroylhexaglutamates with cytoplasm;Carl;J. Nutr.,1995

4. Simultaneous measurement of one-carbon and polyglutamate derivatives of folic acid in rat liver using enzymatic interconversions of folates followed by ternary complex formation with thymidylate synthetase and 5-fluorodeoxyuridylic acid: Standardization of the method;Carl;J. Nutr.,1995

5. Phenytoin treatment and folate supplementation affect folate concentrations and methylation;Carl;J. Nutr.,1991

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