Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring-Reference-Cited by-同舟云学术

Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring

Published:2022-12-07 Issue:3 Volume:87 Page:308-313
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Moussavi Mahta¹,Cuskelly Annalisa²,Jung Yoonsung¹,Hodgson Deborah M²,Barouei Javad¹³

Affiliation:

1. Cooperative Agricultural Research Center, Prairie View A&M University , Prairie View, TX , USA

2. Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle , Callaghan, NSW, Australia

3. Integrated Food Security Research Center, Prairie View A&M University , Prairie View, TX , USA

Abstract

ABSTRACTCorticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.

Funder

University of Newcastle Strategic Pilot Research

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbac199/48497511/zbac199.pdf

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