ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†-Reference-Cited by-同舟云学术

ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†

Published:2020-05-19 Issue:3 Volume:103 Page:449-451
ISSN:0006-3363
Container-title:Biology of Reproduction
language:en
Short-container-title:

Author:

Verma Saguna¹,Saksena Sarini²,Sadri-Ardekani Hooman³⁴

Affiliation:

1. Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

2. Columbian College of Arts & Sciences, The George Washington University, DC, USA

3. Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA

4. Department of Urology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

Abstract

Expression of angiotensin-converting enzyme 2, receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is high in the testes, therefore SARS-CoV-2 infection and its association with male reproductive health should be investigated in male coronavirus disease 2019 patients.

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,General Medicine,Reproductive Medicine

Link

http://academic.oup.com/biolreprod/advance-article-pdf/doi/10.1093/biolre/ioaa080/33380295/ioaa080.pdf

Reference10 articles.

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4. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in Spermatogonia, Leydig and Sertoli cells;Wang;Cells,2020

5. Angiotensin-converting enzymes play a dominant role in fertility;Pan;Int J Mol Sci,2013

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