Prediction of new likely emergent amino acid point mutations from USA, UK, Italy, France, Brazil, and India SARS-CoV-2 variants: a possible source for more reliable cocktail coronavirus vaccine

Abstract

Abstract Objectives The interaction between genome components of the vaccines, host cells, and SARS-CoV-2 variants can cause mutation of amino acids at high random frequency. Hence, the present study is aimed at using the codon bases—amino acids components of some available strains with a view to determining new likely emergent strains of SARS-CoV-2. Methods Some genome sizes and lengths of SARS-CoV-2 variants were searched from literatures and other parameters were calculated. Point mutation of a single amino acid was deduced from 2/3 of sets of codon bases responsible for expression of amino acids. One base pair of 0.0047 nm Codon Base Table was used to deduce the likely missense amino acids at probability of one-twentieth. Key findings New generated codon bases gave rise to new emergent strains of varying numbers of amino acid pairs. Amino acids have reappeared and disappeared in some strains. Nine strains altogether have shown stop codon bases and the remaining strains have a tendency to form stop codons. Adenine has the highest frequency of the stop codon bases whereas cytosine is not among stop codons. A total of 906 new variants were deduced from 54 coronavirus strains which initially lacked stop codons. The newly predicted strains may become less pathogenic and could serve as immunogens via glycosylation. Strains with a higher number of codon bases undergo mutation faster and may end up in stop codons. Conclusion Hence the likely emergent strains could be less virulent, less pathogenic, and may fom glycans that could serve as a source for manufacturing of more reliable coronavirus vaccines.