Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration

Author:

Saveh-Shemshaki Nikoo12,Barajaa Mohammed A3,Otsuka Takayoshi1ORCID,Mirdamadi Elnaz S12,Nair Lakshmi S1245,Laurencin Cato T12456ORCID

Affiliation:

1. The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut , Farmington, CT 06030, USA

2. Department of Biomedical Engineering, University of Connecticut , Storrs, CT 06269, USA

3. Department of Biomedical Engineering, Imam Abdulrahman Bin Faisal University , Dammam 31451, Saudi Arabia

4. Department of Orthopedic Surgery, University of Connecticut Health Center , Farmington, CT 06030, USA

5. Department of Materials Science and Engineering, University of Connecticut , Storrs, CT 06269, USA

6. Department of Chemical & Biomolecular Engineering, University of Connecticut , Storrs, CT 06269, USA

Abstract

Abstract Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff (RC) tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears (RCTs). Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials (EAMs) on the regeneration of electrically excitable tissues such as skeletal muscle. Here, we review the most important biological mechanism of RC muscle degeneration. Further, the review covers the recent studies on EAMs for muscle regeneration including RC muscle. Finally, we will discuss the future direction toward the application of EAMs for the augmentation of RCTs.

Funder

DHHS

NIH

NIAMS

Regenerative Engineering of Complex Musculoskeletal Tissue and Joints

Imam Abdulrahman Bin Faisal University

Publisher

Oxford University Press (OUP)

Subject

Biomaterials

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