Effects of Early Erythropoietin Therapy on the Transfusion Requirements of Preterm Infants Below 1250 Grams Birth Weight-Reference-Cited by-同舟云学术

Effects of Early Erythropoietin Therapy on the Transfusion Requirements of Preterm Infants Below 1250 Grams Birth Weight

Published:2024-09 Issue: Volume: Page:189-194
ISSN:
Container-title:50 Studies Every Neonatologist Should Know
language:en
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Author:

Curley Anna E.

Abstract

Abstract This multicenter randomized controlled study was composed of 2 concurrent trials. Infants in both trials were randomized to erythropoietin 400 U/kg 3 times weekly or placebo. Trial 1 aimed to decrease the number of transfusions received among infants 401 to 1000 g birth weight. One hundred and seventy-two infants were randomized to erythropoietin or placebo. There was no difference in the number of transfusions (4.3 [standard deviation 3.6] versus 5.2 [4.2], p = 0.09). Trial 2 aimed to decrease the percentage of transfused infants 1001 to 1250 g birth weight. One hundred and eighteen infants were randomized, of which 22 of 59 (37%) of treated infants versus 27 of 59 (46%) placebo infants were transfused (p = 0.25). Trial 2 was discontinued early due to reduced likelihood of demonstrating a treatment effect.

Publisher

Oxford University PressNew York

Reference5 articles.

1. Effects of early erythropoietin therapy on the transfusion requirements of preterm infants below 1250 grams birth weight: a multicenter, randomized, controlled trial.;Pediatrics,2001

2. The effect of erythropoietin on the transfusion requirements of preterm infants weighing 750 grams or less: a randomized, double-blind, placebo-controlled study.;J Pediatr,1997

3. Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial.;Pediatrics

4. 4. Ohlsson A, Aher SM. Early erythropoiesis-stimulating agents in preterm or low birth weight infants. Cochrane Database Syst Rev. 2020;2(2):CD004863.

5. Neurodevelopmental outcome and growth at 18 to 22 months’ corrected age in extremely low birth weight infants treated with early erythropoietin and iron.;Pediatrics,2004