Chapter one provides an overview of syringe pumps and CSCIs. The reader is introduced to the development of the syringe driver, or pump, and the need for a CSCI. Specific indications for a CSCI are described. Practical advice about how to avoid and manage the risks of an infusion site reaction are presented, as well as ten FAQs related to the set-up and use of the syringe pump. The currently available syringe pumps are then further discussed in more detail. The chapter closes with a discussion about the risk of needlestick injury, with reference to current legislation and techniques that can reduce the risk.