Physiology—glucose reabsorption in the proximal tubule is carried out by two different pairs of apical Na+-dependent (SGLT1 and 2) and basolateral Na+-independent (GLUT1 and 2) glucose transporters.
Clinical disorders—abnormalities in renal glucose transport can be seen in association with other defects of proximal tubular transport (Fanconi syndrome, see below). Familial renal glycosuria is a rare autosomal recessive condition caused by mutations in the SGLT2-encoding gene, ...