Precision or personalized health is an emerging trend that has implications for integrative nursing. Incorporating precision health through the principles of integrative nursing allows for a whole-person-centered care approach. Precision health focuses on prevention and provides for a holistic view of the patient that takes into account all factors such as environment, health behaviors, genetic potential, and current lifestyle choices. The focus on the whole person has the ability to shift the paradigm of health to look upstream and has implications for personalized wellness by combining biometric, genetic, and environmental data to develop a scientific personalized wellness plan. This chapter discusses the precision health initiative and the alignment of precision health and integrative nursing. Specific exemplars along with resources are used to highlight the intersection of precision health and integrative nursing.