Abstract
Abstract
Bipolar disorder and schizophrenia share some biological and clinical features, and neuroimaging research may provide insights into mechanistic relationships between the two disorders. This chapter reviews studies using structural magnetic resonance imaging (MRI), diffusion tensor imaging, task-related and resting state functional MRI, and magnetic resonance spectroscopy techniques to collect data from individuals with bipolar disorder and schizophrenia in the same experiment. The chapter concludes that these two disorders share many neurobiological features, but some distinctions are also evident. A high degree of heterogeneity and lack of replication among published studies hampers the ability to draw strong conclusions concerning some important details such as relationship between brain abnormalities and clinical presentation and treatment effects. Technological advances coupled with precise phenotyping are likely to provide deeper insights into the relationship between bipolar disorder and schizophrenia.