Psycho-oncology, Stress Processes, and Cancer Progression

Author:

Antoni Michael H.,Knight Jennifer M.,Lutgendorf Susan K.

Abstract

Epidemiological, experimental, and clinical research has shown that chronic stress and adversity are associated with a wide range of biobehavioral processes that may influence cancer progression. These include neuroendocrine alterations (sympathetic nervous system, hypothalamic pituitary adrenal axis), which can up-regulate inflammation and down-regulate antitumor immunity. Such changes may render immune cells less able to detect and destroy tumor cells and may enhance their ability to promote an inflammatory microenvironment. Additionally, neuroendocrine signaling in the tumor microenvironment may promote tumor growth mechanisms, such as angiogenesis, epithelial mesenchymal transition, invasion, and metastasis. Because modifying biobehavioral stress processes might improve cancer health outcomes, randomized controlled trials have tested interventions that can be considered stress management in patients with different forms of cancer. Many trials demonstrate the physical-, mindfulness-, and cognitive-behavioral therapy–based stress management interventions and pharmacologic blockade of stress-related pathways can affect biobehavioral processes in cancer patients and survivors. Importantly, research has now linked stress management–associated changes in these biobehavioral processes early in treatment with long-term health outcomes in some common cancers. We summarize evidence from basic science studies for these biobehavioral associations in multiple cancer models, and from clinical trials for the efficacy of interventions capable of modulating both psychological and biological processes in cancer patients.

Publisher

Oxford University Press

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3