The world is in the throes of a global health, economic, and mental health crisis with severe physical, societal, and economic ramifications. Modern mental health problems are characterized by their complexity, multisystemic nature, and broad societal impact, making them poorly suited to siloed approaches of thinking and innovation. To solve the unprecedented complexities and challenges associated with the current global crisis, a paradigm shift is needed. Convergence science integrates knowledge, tools, and thought strategies from various fields and is the focal point where novel insights arise. In the context of mental health, convergence involves integration of scientists, clinicians, bioinformaticists, global health experts, engineers, technology entrepreneurs, medical educators, caregivers, and patients; synergy between government, academia, and industry is also vital. A convergence mental health approach will lead to improved outcomes for patients and healthcare systems. Predicate examples of convergence science in adjacent fields to mental health provide a model for the path forward. Further, within the field of mental health, there are examples of convergence science currently in action that include early-stage companies, neuroscience initiatives, public health projects, and unconventional funding mechanisms. The world has a historic opportunity to leverage convergence science to lead to a new era of innovation and progress in global mental health. Contributions for this book come from authors affiliated with the Milken Institute, Asia Pacific Economic Cooperation, Organization for Economic Co-operation and Development, the National Academies of Science, Medicine and Engineering, Stanford University, and Harvard University. This book is written for practitioners and leaders in mental health innovation, including clinicians, researchers, policymakers, investors, entrepreneurs, and philanthropists.