Ketogenic Diet in Status Epilepticus

Abstract

Abstract Overall, 15% of status epilepticus cases admitted to the hospital become super-refractory. In adults, super-refractory status epilepticus has a high mortality rate (> 60%). Although the risk of death is low in the pediatric population, the risk of subsequent neurologic morbidity and cognitive problems is high. The therapeutic intervention aims to reduce its duration, mortality, and short- and long-term comorbidities. The ketogenic diet can be effective: the multiple mechanisms of action of KD, lack of interactions with other drugs, and both enteral and parenteral administration possibilities make it a good choice for refractory status epilepticus. The inherent combination of mechanisms can mimic polytherapy, an approach that is suggested to be a good choice. More research and clinical trials are needed.