Non-Respiratory Function of Lungs

Abstract

Abstract This chapter discusses the multiple functions of the lung beyond that of gas exchange. Physical barriers provide a first line of defense against inhaled particles and pathogens from the outside world. These materials are trapped and filtered within the lungs, along with endogenous particles such as circulating emboli. Defense mechanisms also include filtration of both endogenous and exogenous materials. Metabolic activity of the lungs can modify drugs as well as circulating hormones. The cytochrome P450 system in the lungs aids in this process. Additionally, the highly compliant pulmonary microvasculature can serve as a reservoir of blood that is adaptable to varied demands.