Liquid Chromatographic Determination and Mass Spectrometric Confirmation of Chloramphenicol Residues in Animal Tissues-Reference-Cited by-同舟云学术

Liquid Chromatographic Determination and Mass Spectrometric Confirmation of Chloramphenicol Residues in Animal Tissues

Published:1983-11-01 Issue:6 Volume:66 Page:1521-1526
ISSN:0004-5756
Container-title:Journal of AOAC INTERNATIONAL
language:en
Short-container-title:

Author:

Bories George S F¹,Peleran Jean-Claude¹,Wal Jean-Michel¹

Affiliation:

1. Laboratoire de Recherches sur les Additifs Alimentaires, INRA, 180, Chetnin de Tournefeuille, 31300 Toulouse, France

Abstract

Abstract A rapid and sensitive liquid chromatographic (LC) method for determination of trace amounts of chloramphenicol (CP) in animal tissues has been developed. Chloramphenicol identity is confirmed by gas chromatography-mass spectrometry (GC-MS). CP can be routinely quantitated by LC at 10 ppb with 75% recovery, and GC-MS selected ion monitoring permits complete identification at concentrations as low as 5 ppb. Residues were determined in chicken tissues after intramuscular injection of CP. Depletion was rapid with no residues detected in muscle after 8 h, while 15-30 ppb CP was still determined and identified in the liver.

Publisher

Oxford University Press (OUP)

Subject

General Chemistry

Link

http://academic.oup.com/jaoac/article-pdf/66/6/1521/32511823/jaoac1521.pdf

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Determination of chloramphenicol residues in fish meats by liquid chromatography–atmospheric pressure photoionization mass spectrometry;Journal of Chromatography A;2003-09

2. Determination and Confirmation of Chloramphenicol Residues in Swine Muscle and Liver;Journal of Food Science;2002-01