Affiliation:
1. Div. of Toxicol., Armed Forces Inst. of Pathol., Washington, DC 20306-6000
Abstract
Abstract
Knowledge about the stability of drugs in biological specimens can be critical to the proper interpretation of results. Stability of drugs of abuse in biological specimens has been recently reviewed (1). Two drugs for which limited stability data have been published are phencyclidine (PCP) and amphetamine (AMP)/methamphetamine (MA). Therefore, we undertook a stability study of these drugs in urine specimens. Urine samples from five drug-free individuals were fortified with PCP, AMP, and MA at three concentrations. These specimens were divided into aliquots; one was stored at room temperature (25 °C), the other in the refrigerator (4 °C). Over a six-month period, aliquots of each specimen were quantified by gas chromatography-mass spectrometry (2). A known control was analyzed with each batch; results were within 10% of the expected value.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
13 articles.
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1. Drug stability in forensic toxicology;WIREs Forensic Science;2023-02-21
2. Issues Affecting Interpretation;Handbook of Forensic Medicine;2022-06-27
3. Drug Stability;Postmortem Toxicology;2019
4. Issues Affecting Interpretation: Stability and Artefacts;Handbook of Forensic Medicine;2014-03-14
5. Phencyclidine and Phencyclidine Analogues;Medical Toxicology of Drug Abuse;2012-02-02