Affiliation:
1. From the Department of Biochemistry, Memorial Sloan-Kettering Cancer Center, New York, N.Y. 10021
Abstract
Abstract
Since Warburg and his associates reported in 1924 that cancer tissue exhibits a greater rate of aerobic glycolysis than normal tissue, there have been numerous efforts to define enzymatic defects in cancer tissue. Attempts have been made to use enzyme assays in the diagnosis of cancer and in following the course of the disease. This review considers in this regard the role of organ-specific enzymes (amylase, phosphohydrolases, etc.) as well as the more ubiquitous glycolytic enzymes. The usefulness of the assay of isoenzymes in serum, as well as in tissue of cancer patients, is discussed and the role of enzymes in chemotherapy considered
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
61 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献