Affiliation:
1. Mount Sinai Hospital Medical Center and The University of Health Sciences/The Chicago Medical School, California Ave. at 15th St., Chicago, Ill. 60608
Abstract
Abstract
Three commercially available kits for determining serum thyroxine (T4) by column were evaluated. Results with all were less than satisfactory, but a series of changes in the Oxford method resulted in increased reproducibility, substantially improved recovery, and extended linearity of the standard curve. Results compared well with the thyrometabolic status of patients and normal individuals. The 95% confidence limits for 219 "normal" hospital employees were 2.9-6.2 µg/100 ml. The suggested normal range for 241 clinically euthyroid patients is 2.5-6.0 µg/100 ml. The coefficient of correlation between results of the proposed method and of the PBI method was 0.30; for the T4 by the Murphy—Pattee method it was 0.75.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
6 articles.
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1. The snake thyroid gland;General and Comparative Endocrinology;1974-05
2. Iodine Contamination in Iodometric Measurements of Thyroid Hormones;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1974-01
3. Accuracy and Standardisation of Serum Thyroxine Assays;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1974-01
4. Accuracy and Standardisation of Serum Thyroxine Assays;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1974-01
5. Modification of column chromatography in T4 analysis;Clinical Biochemistry;1973-03