Abstract
Abstract
Methylecgonine is a common metabolite of cocaine in man. We prepared methylecgonine and developed thin-layer chromatographic and gas-chromatographic methods for its detection in urine. Seventy urine specimens from our drug screening laboratory were tested by our method and by EMIT. Both methods were positive for 26 urines, and both were negative for 42 urines. The other two urines were shown to contain cocaine by GC/MS, and no detectable metabolites. We thus demonstrated that detection of methylecgonine and cocaine is as sensitive a test for cocaine use as EMIT.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Cocaine;Karch's Pathology of Drug Abuse, Fifth Edition;2015-09-03
2. Cocaine;Karch's Pathology of Drug Abuse, Fourth Edition;2008-12-15
3. An Amperometric Immunosensor for Cocaine;Electroanalysis;1998-04
4. Screening for Drugs of Abuse. I: Opiates, Amphetamines and Cocaine;Annals of Clinical Biochemistry: International Journal of Laboratory Medicine;1995-03
5. The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS);Forensic Science International;1994-06