Emergency Gas—Liquid Chromatographic Determination of Barbiturates and Glutethimide in Serum-Reference-Cited by-同舟云学术

Emergency Gas—Liquid Chromatographic Determination of Barbiturates and Glutethimide in Serum

Published:1970-07-01 Issue:7 Volume:16 Page:587-593
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Sine H E¹,McKenna M J¹,Rejent T A¹,Murray M H¹

Affiliation:

1. Clinical Laboratory, The Genesee Hospital, 224 Alexander St., Rochester, N.Y. 14607 (H.E.S., M.J.McK., and M.H.M.) and the Erie County Toxicology Laboratory, Buffalo, N.Y. 14215 (T.A.R.)

Abstract

Abstract A method is presented for the rapid gas chromatographic determination of barbiturates and glutethimide in serum, suitable for use in clinical emergencies. The sample is prepared for gas chromatography by acidification and a single extraction with chloroform. From 70 to 100% of the various barbiturates and glutethimide are analytically recovered, with a coefficient of variation of 8 to 10% for the method. During a 10-month clinical evaluation (87 requested determinations), 34 analyses (39% of the samples submitted) were positive for barbiturates, glutethimide, or both.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/16/7/587/32820286/clinchem0587.pdf

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1. Glutethimide;Analytical Profiles of Drug Substances;1976

2. Possible interference by a metabolite in gas chromatographic assays for glutethimide which employ certain non-selective liquid phases;Journal of Chromatography A;1973-12

3. Gas chromatographic analysis of the commonly prescribed barbiturates at therapeutic and overdose levels in plasma and urine;Journal of Chromatography A;1973-11

4. A rapid method for the determination of therapeutic barbiturate levels in serum using gas-liquid chromatography;Clinica Chimica Acta;1973-02

5. Rapid Identification of Drugs in Body Fluids of Comatose Patients;Clinical Toxicology;1973-01