Affiliation:
1. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conn. 06510
Abstract
Abstract
We describe a procedure for measuring the concentration of cocaine in plasma by gas chromatography, with use of a nitrogen detector. The procedure was tested on patients receiving intranasal cocaine for topical anesthesia. The propyl ester of benzoylecgonine is used as an internal standard. The lower limit of sensitivity of the procedure is 5-10 µg of cocaine per liter of plasma. The coefficients of variation are 5.3% and 3.0% for concentrations of 50 and 100 µg/liter, respectively.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Cited by
42 articles.
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1. Cocaine;Karch's Pathology of Drug Abuse, Fifth Edition;2015-09-03
2. Cocaine;Karch's Pathology of Drug Abuse, Fourth Edition;2008-12-15
3. The Effects of Cocaine on Gonadal Steroid Hormones and LH in Male and Female Rhesus Monkeys;Neuropsychopharmacology;2004-06-16
4. Ovarian Steroid Hormone Modulation of the Acute Effects of Cocaine on Luteinizing Hormone and Prolactin Levels in Ovariectomized Rhesus Monkeys;Journal of Pharmacology and Experimental Therapeutics;2003-10-17
5. Drugs of Abuse, Analysis of;Encyclopedia of Analytical Chemistry;2000-10-30