Affiliation:
1. Analytical Development Department, Lilly Research Laboratories, Indianapolis, Ind. 46206
Abstract
Abstract
A gas-chromatographic method is described for determination of codeine and norcodeine in human plasma. The method is specific, sensitive, and precise. It was developed for use in bioavailability studies of therapeutic doses of codeine sulfate. After ingestion of a 60-mg codeine sulfate tablet, mean peak codeine concentration in plasma was 107 µg/liter at 1.0 hour. No measurable concentration of norcodeine was found in the plasma by this method.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
22 articles.
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