Fluorometric Screening Method for Detecting Benzodiazepines in Blood and Urine-Reference-Cited by-同舟云学术

Fluorometric Screening Method for Detecting Benzodiazepines in Blood and Urine

Published:1975-12-01 Issue:13 Volume:21 Page:1976-1979
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Valentour James C¹,Monforte Joseph R²,Lorenzo Beverly¹,Sunshine Irving¹

Affiliation:

1. Cuyahoga County Coroner's Office, 2121 Adelbert Road, Cleveland, Ohio 44106; and the Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

2. Wayne County Medical Examiner's Office, 400 E. Lafayette St., Detroit, Mich. 48226

Abstract

Abstract We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to their respective benzophenones and converted to highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) in blood and gastric contents are semiquantitatively evaluated and compared to results of gas-chromatographic determinations.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/21/13/1976/32807134/clinchem1976.pdf

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