Screening Method for Detection of Drugs of Abuse in Human Urine

Author:

Weissman Norman1,Lee Lowe Mei1,Beattie John M1,Demetriou James A1

Affiliation:

1. Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405

Abstract

Abstract A simple, convenient method is described for the detection in human urine of three major classes of drugs of abuse: amphetamines, barbiturates, and alkaloids. The drugs are adsorbed from urine by a column of non-ionic resin (Amberlite XAD-2), eluted with methanol, and chromatographed on a thin-layer silica gel plate. The drugs are made visible and identified by a series of procedures involving exposure to ultraviolet radiation, heat treatment, sequential spraying with group-specific reagents, and measurement of Rf values. Detection limits for 5-ml urine specimens are: 0.4 µg per ml for amphetamines and barbiturates, and 0.8 g per ml for alkaloids. The test requires 6 h to perform. One technologist can process 50 specimens per day.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A Note on the Use of Novel Bonded Phase Adsorbents for the Extraction of Drugs of Abuse from Biological Matrices;Sample Preparation for Biomedical and Environmental Analysis;1994

2. Therapeutic Drug Levels and Toxicology Screen;Emergency Medicine Clinics of North America;1986-05

3. The Analysis of Narcotics;Analytical Methods in Human Toxicology;1986

4. Macroreticular resin xad-2 as a catalyst for the simultaneous extraction derivatization of organic acids from water;Journal of Chromatography A;1984-01

5. NOVEL DERIVATIZATION METHODS IN THE ANALYSIS OF CANNABINOIDS;The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects;1984

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