Abnormal Concentrations of Nickel in Serum in Cases of Myocardial Infarction, Stroke, Burns, Hepatic Cirrhosis, and Uremia

Author:

McNeely Michael D1,Sunderman F William1,Nechay Maria W1,Levine Howard1

Affiliation:

1. University of Connecticut School of Medicine, Newington, Conn. 06111, and New Britain General Hospital, New Britain, Conn. 06052

Abstract

Abstract Nickel concentrations were measured by atomic absorption spectrometry in sera. The mean concentration of nickel in sera of 47 healthy adults was 2.6 SD ± 0.8) µg/liter. Abnormally high mean concentrations (µg/liter) of serum nickel were found in patients with: (a) acute myocardial infarction (13-36 h after onset), mean = 5.2 ± 2.8, N = 33, P <0.001; (b) acute stroke (37-72 h after onset), mean = 4.5, N = 12, P <0.005; and (c) acute burns (>25% body surface, 37-72 h after injury), mean = 7.2, N = 3, range = 4.1-10.9. Diminished mean concentrations of serum nickel were found in patients with: (a) hepatic cirrhosis, mean = 1.6 ± 0.8, N = 18, P <0.005; and (b) chronic uremia, mean = 1.7 ± 0.7, N = 12, P = <0.005. Normal mean concentrations of serum nickel were found in patients with: (a) acute myocardial ischemia without infarction (13-36 h after onset), mean = 3.3 ± 1.6, N = 22; (b) acute trauma with fractured bones (13-36 h after injury), mean = 2.7 ± 0.9, N = 19; (c) acute delirium tremens (13-36 h after admission), mean = 2.3 ± 0.9, N = 25; and (d) muscular dystrophy, mean = 2.3 ± 1.4, N = 10. In sera collected from 12 mothers immediately after normal delivery, the mean concentration of nickel was 3.0 ± 1.2 µg/liter, the same values as for sera from the umbilical cords of their 12 full-term infants.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Cited by 51 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3