Nitrogen Dioxide Formation during Inhaled Nitric Oxide Therapy-Reference-Cited by-同舟云学术

Nitrogen Dioxide Formation during Inhaled Nitric Oxide Therapy

Published:1999-03-01 Issue:3 Volume:45 Page:382-387
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Sokol Gregory M¹,Van Meurs Krisa P²,Wright Linda L³,Rivera Oswaldo⁴,Thorn William J⁵,Chu Pamela M⁵,Sams Robert L⁵

Affiliation:

1. Department of Pediatrics, Indiana University, Indianapolis, IN 46202

2. Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94304

3. Neonatal Network, National Institute of Child Health and Human Development, Bethesda, MD 20892

4. Department of Biomedical Engineering, Children’s Hospital National Medical Center, Washington, DC 20010

5. Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899

Abstract

Abstract Background: Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial. Methods: The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2 concentrations below 2 ppm accurately was overcome by the use of tunable diode laser absorption spectroscopy. Results: Using a second-order model, the rate constant, k, for NO2 formation was determined to be (1.19 ± 0.11) × 10−11 ppm−2s−1, which is in basic agreement with evaluated data from atmospheric literature. Conclusions: Inhaled NO can be delivered safely in a well-designed, continuous flow neonatal ventilatory circuit, and NO2 formation can be calculated reliably using the rate constant and circuit dwell time.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/45/3/382/32721987/clinchem0382.pdf

Reference25 articles.

1. Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

2. Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide

3. Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: Dose response

4. Effect of nitric oxide on the survival rate and incidence of lung injury in newborn lambs with persistent pulmonary hypertension

5. Prolonged Inhalation of Low Concentrations of Nitric Oxide in Patients with Severe Adult Respiratory Distress Syndrome

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Comprehensive Review of Inhaled Nitric Oxide Therapy: Current Trends, Challenges, and Future Directions;Cureus;2024-02-04

2. Mechanistic analysis of the photolytic decomposition of solid-state S-nitroso-N-acetylpenicillamine;Nitric Oxide;2024-01

3. A miniaturized photodiode-based chemiluminescence sensor for measurement of fractional exhaled nitric oxide;Sensors and Actuators B: Chemical;2023-11

4. Development of nitric oxide generators to produce high-dose nitric oxide for inhalation therapy;Nitric Oxide;2023-09

5. Inhaled nitric oxide (iNO) administration in intubated and nonintubated patients: Delivery systems, interfaces, dose administration, and monitoring techniques;Nitric Oxide in Health and Disease;2023