Effects of Phenyl Benzo-γ-Pyrone Derivatives (Flavonoids) on Blood Cell Aggregation: Basis for a Concept of Mode of Action

Abstract

Abstract Flavonoids were investigated for activity on blood cell aggregation. A procedure for measuring serial erythrocyte sedimentation rate (ESR) was used to test the effect of five flavonoids (hesperidin, quercetin, rutin, tangeretin, and naringin) on aggregation in vitro. The activity of the flavonoids was compared with that of quinine and low molecular weight dextran (LMD), both of which demonstrably decrease blood cell aggregation in vivo and in vitro. At a blood concentration of 50 µmol/liter the flavonoids, quinine, and LMD all showed significant effects (P < 0.05) on aggregation, the order of retardation of ESR being rutin < quercetin < LMD < hesperidin < quinine < tangeretin. Naringin-treated blood had a higher ESR than control blood. The effect of flavonoids on blood cell aggregation suggests how they may act against increased capillary permeability and fragility, reduce symptoms in disease, and protect against effects of various traumas and stresess.