An Improved Method for Measuring Blood Concentrations of Phenylpyruvic Acid-Reference-Cited by-同舟云学术

An Improved Method for Measuring Blood Concentrations of Phenylpyruvic Acid

Published:1971-05-01 Issue:5 Volume:17 Page:378-381
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Coburn S P¹,Mahuren J D¹,Fuller R W¹

Affiliation:

1. Fort Wayne State Hospital and Training Center, 801 E. State Blvd., Fort Wayne, Ind. 46805 (S. P. C. and J. D. M.); and Lilly Research Laboratories, Indianapolis, Ind. 46206

Abstract

Abstract We describe an improved determination of phenylpyruvic acid (PPA) in blood plasma by ultraviolet spectrophotometric measurement of an enol— borate complex. Sensitivity and recovery are well suited for accurate analysis in the range of 1.25 to 25 mg/liter. Sera from 10 fasting phenylketonuric subjects averaged 15.3 mg/liter (range, 4.8 to 25.0 mg/liter). A pronounced diurnal rhythm in plasma PPA, with peak concentrations occurring between noon and 6 p.m., was detected in patients with untreated phenylketonuria.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/17/5/378/32822086/clinchem0378.pdf

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