Rapid Gas—Liquid Chromatographic Determination of Carbamazepine in Plasma-Reference-Cited by-同舟云学术

Rapid Gas—Liquid Chromatographic Determination of Carbamazepine in Plasma

Published:1974-04-01 Issue:4 Volume:20 Page:492-493
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Perchalski Robert J¹,Wilder B J¹

Affiliation:

1. Veterans Administration Hospital, Gainesville, Fla. 32606 (R. J. P. and B. J. W.); and the Department of Medicine, University of Florida, Gainesville, Fla. 32610 (B. J. W.)

Abstract

Abstract A rapid, sensitive method is described for the quantitative determination of carbamazepine in plasma. The coefficient of variation of replicate extractions is typically within 5%. This procedure can be completed in 45 min and the derivatives formed by the reaction of the drug and internal standard with dimethylformamide dimethyl acetal are stable for at least 17 h. The lower limit of detection is 0.2 µg/ml of plasma.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/20/4/492/32823431/clinchem0492.pdf

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