Application of Microarrays to the Analysis of Gene Expression in Cancer-Reference-Cited by-同舟云学术

Application of Microarrays to the Analysis of Gene Expression in Cancer

Published:2002-08-01 Issue:8 Volume:48 Page:1170-1177
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Macgregor Pascale F¹,Squire Jeremy A²³⁴

Affiliation:

1. Microarray Centre, Clinical Genomics Center, University Health Network, Toronto, Ontario, M5G 1L7 Canada

2. Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2L9 Canada

3. Departments of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2L9 Canada

4. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 2L9 Canada

Abstract

Abstract Molecular diagnostics is a rapidly advancing field in which insights into disease mechanisms are being elucidated by use of new gene-based biomarkers. Until recently, diagnostic and prognostic assessment of diseased tissues and tumors relied heavily on indirect indicators that permitted only general classifications into broad histologic or morphologic subtypes and did not take into account the alterations in individual gene expression. Global expression analysis using microarrays now allows for simultaneous interrogation of the expression of thousands of genes in a high-throughput fashion and offers unprecedented opportunities to obtain molecular signatures of the state of activity of diseased cells and patient samples. Microarray analysis may provide invaluable information on disease pathology, progression, resistance to treatment, and response to cellular microenvironments and ultimately may lead to improved early diagnosis and innovative therapeutic approaches for cancer.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/48/8/1170/32730224/clinchem1170.pdf

Reference44 articles.

1. High density synthetic oligonucleotide arrays

2. Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

3. Light-Directed, Spatially Addressable Parallel Chemical Synthesis

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