Concurrent Assay of Phenobarbital and Diphenylhydantoin in Plasma by Vapor-Phase Chromatography

Author:

Van Meter J C1,Buckmaster H S1,Shelley L L1

Affiliation:

1. Mosier Research Laboratory, New Castle State Hospital, New Castle, Ind. 47362

Abstract

Abstract The weakly acidic phenobarbital and diphenylhydantoin, separated from interfering substances by simple solvent partition, are estimated concurrently by vapor-phase chromatography. Solid sample injection and internal standard (primidone) are used. The entire procedure can be completed within 2 h after venipuncture. Both drugs could be measured after therapeutic doses have been administered.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Cited by 25 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The current status of phenobarbitone use in childhood;The Indian Journal of Pediatrics;1985-11

2. Determination of antiepileptic drugs;Journal of Chromatography B: Biomedical Sciences and Applications;1985-05

3. Phenytoin;Analytical Profiles of Drug Substances;1984

4. Drug level monitoring in paediatric practice.;Archives of Disease in Childhood;1980-02-01

5. Neoplasms;Neurological Clinical Pharmacology;1980

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