Determination of Caffeine in Serum and Urine-Reference-Cited by-同舟云学术

Determination of Caffeine in Serum and Urine

Published:1969-08-01 Issue:8 Volume:15 Page:661-668
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Routh J I¹,Shane N A¹,Arredondo E G¹,Paul W D¹

Affiliation:

1. Departments of Biochemistry and of Physical Medicine and Rehabilitation, University of Iowa, Iowa City, Iowa 52240 and Bristol-Myers Products Division, Hillside, NJ

Abstract

Abstract The method of Axelrod and Reichenthal for the determination of caffeine in serum and urine was modified. The benzene used in the extraction of caffeine was shown to alter the spectral absorbance curve of this compound. A method based on the differential absorbance spectrums of caffeine and related compounds is described. Both methods exhibited satisfactory replication, recovery of added caffeine, and comparable serum levels of the drug.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/15/8/661/32819868/clinchem0661.pdf

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