Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

Author:

Ishii Junnichi1,Wang Jian-hua1,Naruse Hiroyuki1,Taga Shinn1,Kinoshita Masatomo1,Kurokawa Hiroshi1,Iwase Masatsugu1,Kondo Takeshi1,Nomura Masanori1,Nagamura Youichi2,Watanabe Yoshihiko1,Hishida Hitoshi1,Tanaka Takao3,Kawamura Keishiro3

Affiliation:

1. Department of Internal Medicine, Fujita Health University School of Medicine, 1–98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470–11, Japan

2. Department of Clinical Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan

3. Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan

Abstract

Abstract We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913–0.979] and myoglobin (0.895, 95% CI = 0.846–0.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.765–0.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2–89.4%), specificity (86.4%, 95% CI = 78.1–94.6%), and predictive accuracy (83.6%, 95% CI = 78.0–89.3%) of H-FABPc >12 μg/L in diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABPc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

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