Affiliation:
1. Department of Chemical Pathology, Westminster Medical School, London SW1P 2AR
Abstract
Abstract
A method is described that allows heavy-chain disease proteins to be simply detected. The sample is electrophoresed in an agarose plate containing kappa and lambda antisera in the lower section, and the relevant heavy-chain antisera in the upper section. Light chains and immunoglobulins containing light chains are precipitated in the lower region. Free "heavy chains" migrate into the upper region, where they are precipitated as a separate rocket. The method is quick, sensitive, and requires little antiserum.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Cited by
22 articles.
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1. Gammapathies monoclonales de signification rénale;Revue Francophone des Laboratoires;2024-03
2. Maladies des chaînes lourdes;Revue Francophone des Laboratoires;2020-04
3. Commentary;Clinical Chemistry;2019-05-01
4. Successful Treatment of ?-Heavy-Chain Disease with Rituximab and Fludarabine;Acta Haematologica;2012
5. Alpha-Heavy Chain Disease;Scandinavian Journal of Haematology;2009-04-24