Affiliation:
1. The Research Institute, The Hospital for Sick Children, Toronto, Canada
Abstract
Abstract
In serum there are two classes of hexosaminidase. One of these is heat-labile and is inactive in children with Tay—Sachs disease. Serum from heterozygotes for Tay—Sachs disease has half the normal activity of the heat-labile enzyme. The heat-labile enzyme can be inactivated by heating serum diluted in buffer for 5 min at 60 °C. We have used this property to develop a reliable, fully automated assay for serum hexosaminidases, which can be used for mass carrier screening programs.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Cited by
35 articles.
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