Recovery of dialysis patients with COVID-19: health outcomes 3 months after diagnosis in ERACODA
Author:
Hemmelder Marc H1, Noordzij Marlies2, Vart Priya2, Hilbrands Luuk B3ORCID, Jager Kitty J4, Abrahams Alferso C5, Arroyo David6, Battaglia Yuri7, Ekart Robert8, Mallamaci Francesca9, Malloney Sharon-Rose10, Oliveira Joao11ORCID, Rydzewski Andrzej12, Sridharan Sivakumar13ORCID, Vogt Liffert14, Duivenvoorden Raphaël3, Gansevoort Ron T2, Franssen Casper F M2, van der Net Jeroen B, Essig Marie, du Buf-Vereijken Peggy W G, van Ginneken Betty, Maas Nanda, van Jaarsveld Brigit C, Bemelman Frederike J, Klingenberg-Salahova Farah, Heenan-Vos Frederiek, Vervloet Marc G, Nurmohamed Azam, Abramowicz Daniel, Verhofstede Sabine, Maoujoud Omar, Malfait Thomas, Fialova Jana, Melilli Edoardo, Favà Alexandre, Cruzado Josep M, Perez Nuria Montero, Lips Joy, Krepel Harmen, Adilovic Harun, Hengst Maaike, Konings Constantijn J A M, Braconnier Philippe, Weis Daniel, Gellert Ryszard, Alferes Daniela G, Radulescu Daniela, Zakharova Elena V, Ambuehl Patrice Max, Guidotti Rebecca, Walker Andrea, Lepeytre Fanny, Rabaté Clémentine, Rostoker Guy, Marques Sofia, Azasevac Tijana, Majstorovic Gordana Strazmester, Katicic Dajana, ten Dam Marc, Krüger Thilo, Brzosko Szymon, Liakopoulos Vassilios, Zanen Adriaan L, Logtenberg Susan J J, Fricke Lutz, Kuryata Olexandr, Slebe Jeroen J P, ElHafeez Samar Abd, Kemlin Delphine, van de Wetering Jacqueline, Reinders Marlies E J, Hesselink Dennis A, van Gestel J Kal-, Eiselt Jaromir, Kielberger Lukas, El-Wakil Hala S, Verhoeven Martine A M, Logan Ian, Canal Cristina, Facundo Carme, Ramos Ana M, Debska-Slizien Alicja, Veldhuizen Nicoline M H, Tigka Eirini, Konsta Maria Anna Polyzou, Panagoutsos Stylianos, Postorino Adele, Cambareri Francesco, Matceac Irina, Nistor Ionut, Covic Adrian, Groeneveld J H M, Jousma Jolanda, van Buren Marjolijn, Diekmann Fritz, Oppenheimer Federico, Blasco Miquel, Pereira Tiago Assis, Soares dos Santos Augusto Cesar, Arias-Cabrales Carlos, Crespo Marta, Llinàs-Mallol Laura, Buxeda Anna, Tàrrega Carla Burballa, Redondo-Pachon Dolores, Jimenez Maria Dolores Arenas, Mendoza-Valderrey Alberto, Martins Ana Cristina, Mateus Catarina, Alvila Goncalo, Laranjinha Ivo, Hofstra Julia M, Siezenga Machiel A, Franco Antonio, Castellano Sandra, Rodríguez-Ferrero Maria Luisa, Manzanos Sagrario Balda, Barrios R Haridian Sosa, Lemahieu Wim, Bartelet Karlijn, Dirim Ahmet Burak, Demir Erol, Sever Mehmet Sukru, Turkmen Aydin, Şafak Seda, Hollander Daan A M J, Kerckhoffs Angele, Büttner Stefan, de Vries Aiko P J, Meziyerh Soufian, van der Helm Danny, Mallat Marko, Bouwsma Hanneke, Petruliene Kristina, Verberk Iris, van der Sande Frank M, Christiaans Maarten H L, Kumar N. Mohan, Luca Marina Di, Tuğlular Serhan Z, Kramer Andrea, Beerenhout Charles, Luik Peter T, Kerschbaum Julia, Tiefenthaler Martin, Watschinger Bruno, Adema Aaltje Y, Stepanov Vadim A, Zulkarnaev Alexey B, Turkmen Kultigin, Gandolfini Ilaria, Maggiore Umberto, Fliedner Anselm, Åsberg Anders, Mjoen Geir, Miyasato Hitoshi, de Fijter Carola W H, Mongera Nicola, Pini Stefano, de Biase Consuelo, Els van de Logt Anne, Maas Rutger, Lebedeva Olga, Lopez Veronica, Reichert Louis J M, Verhave Jacobien, Titov Denis, Parshina Ekaterina V, Zanoli Luca, Marcantoni Carmelita, van Kempen Gijs, van Gils-Verrij Liesbeth E A, Harty John C, Meurs Marleen, Myslak Marek, Lentini Paolo, den Deurwaarder Edwin, Stendahl Maria, Rahimzadeh Hormat, Schouten Marcel, Rychlik Ivan, Cabezas-Reina Carlos J, Roca Ana Maria, Nauta Ferdau, Sahin İdris, Goffin Eric, Kanaan Nada, Labriola Laura, Devresse Arnaud, Diaz-Mareque Anabel, Coca Armando, de Arriba Gabriel, Meijers Björn K I, Naesens Maarten, Kuypers Dirk, Desschans Bruno, Tonnerlier Annelies, Wissing Karl M, Dedinska Ivana, Pessolano Giuseppina, Malik Shafi, Dounousi Evangelia, Papachristou Evangelos, Berger Stefan P, Meijer Esther, Sanders Jan Stephan F, Özyilmaz Akin, Ponikvar Jadranka Buturović, Pernat Andreja Marn, Kovac Damjan, Arnol Miha, Molenaar Femke M, van Zuilen Arjan D, Meijvis Sabine C A, Dolmans Helma, Tantisattamo Ekamol, Esposito Pasquale, Krzesinski Jean-Marie, Barahira Jean Damacène, Gallieni Maurizio, Martin-Moreno Paloma Leticia, Guglielmetti Gabriele, Guzzo Gabriella, Toapanta Nestor, Soler Maria Jose, Luik Antinus J, van Kuijk Willi H M, Stikkelbroeck Lonneke W H, Hermans Marc M H, Rimsevicius Laurynas, Righetti Marco, Islam Mahmud, Heitink-ter Braak Nicole,
Affiliation:
1. Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, CARIM School for Cardiovascular Disease, University of Maastricht, Maastricht, The Netherlands 2. Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands 3. Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands 4. ERA Registry, Department of Medical Informatics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands 5. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands 6. Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain 7. Department of Specialized Medicine, Division of Nephrology and Dialysis, St. Anna University Hospital, Ferrara, Italy 8. Department of Dialysis, Clinic for Internal Medicine, University Medical Center Maribor, Maribor, Slovenia 9. Nephrology, Dialysis and Renal Transplantation Unit, Grande Ospedale Metropolitano di Reggio Cal, Italy 10. Luzerner Kantonsspital, Luzern, Switzerland 11. Centrodial (Outpatient Dialysis Center), São João da Madeira, Portugal 12. Department of Internal Medicine, Nephrology and Transplantation Medicine, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Internal Affairs, Warsaw, Poland 13. Department of nephrology, East and North Hertfordshire NHS Trust, Lister Hospital, Hertfordshire, UK 14. Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands
Abstract
ABSTRACT
Background
Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery in a large cohort of dialysis patients 3 months after their COVID-19 diagnosis.
Methods
We analyzed data on dialysis patients diagnosed with COVID-19 from 1 February 2020 to 31 March 2021 from the European Renal Association COVID-19 Database (ERACODA). The outcomes studied were patient survival, residence and functional and mental health status (estimated by their treating physician) 3 months after COVID-19 diagnosis. Complete follow-up data were available for 854 surviving patients. Patient characteristics associated with recovery were analyzed using logistic regression.
Results
In 2449 hemodialysis patients (mean ± SD age 67.5 ± 14.4 years, 62% male), survival probabilities at 3 months after COVID-19 diagnosis were 90% for nonhospitalized patients (n = 1087), 73% for patients admitted to the hospital but not to an intensive care unit (ICU) (n = 1165) and 40% for those admitted to an ICU (n = 197). Patient survival hardly decreased between 28 days and 3 months after COVID-19 diagnosis. At 3 months, 87% functioned at their pre-existent functional and 94% at their pre-existent mental level. Only few of the surviving patients were still admitted to the hospital (0.8–6.3%) or a nursing home (∼5%). A higher age and frailty score at presentation and ICU admission were associated with worse functional outcome.
Conclusions
Mortality between 28 days and 3 months after COVID-19 diagnosis was low and the majority of patients who survived COVID-19 recovered to their pre-existent functional and mental health level at 3 months after diagnosis.
Funder
European Renal Association Dutch Kidney Foundation Baxter Sandoz
Publisher
Oxford University Press (OUP)
Subject
Transplantation,Nephrology
Cited by
6 articles.
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