CONVINCE in the context of existing evidence on haemodiafiltration

Author:

Vernooij Robin W M12,Bots Michiel L2,Strippoli Giovanni F M34,Canaud Bernard5,Cromm Krister6ORCID,Woodward Mark789,Blankestijn Peter J1,Davenport Andrew,Canaud Bernard,Barth Claudia,Strippoli Giovanni,Hegbrant Jörgen,Fischer Kathrin,Cromm Krister,Török Mariëtta,Woodward Mark,Rose Matthias,Bots Michiel,

Affiliation:

1. Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

3. Department of Emergency and Organ Transplantation, University of Bari, Bari BA, Italy

4. School of Public Health, University of Sydney, Sydney, Australia

5. Montpellier University, School of Medicine, Montpellier, France & Global Medical Office, FMC Deutschland, Bad Homburg, Germany

6. Fresenius Medical Care Deutschland GmbH, Global Medical Office, Bad Homburg, Germany

7. The George Institute for Global Health, University of Oxford, Oxford, UK

8. The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia

9. Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA

Abstract

ABSTRACT Haemodiafiltration (HDF) provides a greater removal of larger solutes and protein-bound compounds than conventional high-flux haemodialysis (HD). There are indications that the patients receiving the highest convection volumes of HDF result in improved survival compared with HD. However, the comparative efficacy of HDF versus HD remains unproven. Here we provide a comparative account of the methodology and aims of ‘the comparison of high-dose HDF with high-flux HD’ (CONVINCE) study in the context of the totality of evidence and how this study will contribute to reaching a higher level of certainty regarding the comparative efficacy of HDF versus HD in people with end-stage kidney disease.

Funder

European Union

Netherlands National Trial Register

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

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